Urease
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Urease in peptic ulcers
Helicobacter pylori is also the cause of peptic ulcers with its manifestation in 55–68% reported cases.cite-ref-tang-24-0[24] This was confirmed by decreased ulcer bleeding and ulcer reoccurrence after eradication of the pathogen.cite-ref-tang-24-1[24] In the stomach there is an increase in pH of the mucosal lining as a result of urea hydrolysis, which prevents movement of hydrogen ions between gastric glands and gastric lumen.cite-ref-mobley-21-4[21] In addition, the high ammonia concentrations have an effect on intercellular tight junctions increasing permeability and also disrupting the gastric mucous membrane of the stomach.cite-ref-mobley-21-5[21]cite-ref-25[25]
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